This paper presents the preliminary results of the first geophysical campaign carried out in 2023 at Chiusi (central Italy, Siena), one of the most important Etruscan city-states of the Northern internal Etruria. The research was conducted in collaboration between the Municipality of Chiusi, the Soprintendenza ABAP-SI and Radaring company. The modern urban area of Chiusi conserves a large stratigraphical palimpsest, with a continuity of occupation from the Bronze age toward Etruscan, Roman and Middle age period. This geophysical campaign aimed to explore some key-site of the historical city-center, in order to better understand the urban layout of the ancient city to elaborate a new archaeological map. The geophysical anomalies identified have been interpreted integrating archaeological and archival data and, in few cases, tested by targeted archaeological excavations.