This year marked the fourth archaeological season undertaken in the Roman amphitheatre of Durrës by the joint Italian-Albanian team. The archaeological data revealed until now confirm once again the dramatic consequences of the earthquake of the year 1273, which caused the destruction of numerous buildings and a large number of deaths among the inhabitants of the city. This latter is confirmed by the discovery of 4 dead individuals (a man, a woman, an infant and a young boy) in the ruins of the palace built at the beginning of the 12th century, ion the south side of the previously destroyed Roman amphitheatre. Underneath the ruins of the medieval palace, the excavations revealed other walls, belonging to an earlier 9th – 10th century AD building; several graves of the 5-6th century AD., associated with materials goods decorated with Christian symbols, were found in the arches and the stairs of the amphitheatre. The revealed data show the transformation of the amphitheatre into a habitation quarter of the Byzantine city, going through an abandonment phase, a funerary and religious occupation, and a reoccupation of residential and commercial character. In the stratigraphic layer associated with these occupation phases, the excavations uncovered numerous ceramic materials, coins, metal objects, including a necklace worn by one of the earthquakes victims. The isotope analyzes of the human skeletons and the remains of animal bones revealed during the excavations will bring important information on diet and health conditions of the ancient inhabitants of the city of Durrës. In addition, the application of modern technologies, such as the micro-gravimetry, geo-seismic, geo-radar, thermoluminescence study of glass and pottery materials, radiocarbon dating, petrographic and geoarchaeological investigations, will bring new information on the history of this complex and multi- phased settlement.